Netherlands capitalised on two England defensive mix-ups in extra time as they came from behind to win their Nations League semi-final 3-1.
Several players from United's first-choice starting line-up, including Paul Pogba, Romelu Lukaku and Jesse Lingard, are resting after the World Cup and could miss the opening league fixture against Leicester City in less than two weeks' time.
Manchester United got their pre-season off to a flying start with a 4-0 rout of rivals Liverpool in Thailand on Tuesday, giving new manager Erik ten Hag a big boost in his first match in charge.
Joe Willock and Callum Wilson scored to give Newcastle United a well-earned 2-0 victory over Manchester United.
Although United made a bright start to their quarter-final second leg at the Nou Camp with Marcus Rashford hitting the crossbar early on, they were soon outclassed by Barca, who eased to a 3-0 win on Tuesday for a dominant 4-0 aggregate victory.
New Everton boss Sean Dyche's reign began with a shock 1-0 victory over English Premier League leaders Arsenal.
Images from Saturday's matches in the Premier League.
Manchester United returned to winning ways in ruthlessly emphatic fashion
Cristiano Ronaldo scored on his return to the starting line-up as Manchester United sealed a place in the Europa League knock-out rounds with a 3-0 victory over Sheriff Tiraspol at Old Trafford on Thursday.
Liverpool's bandwagon rolled on as they crushed Merseyside rivals Everton 5-2
England ran riot by scoring three first-half goals to stun Spain and earn a 3-2 away win in the Nations League on Monday as they moved back into contention in League A Group 4 with their first victory on Spanish soil for 31 years.
Cavani netted an opportunist 71st-minute equaliser after Allan Saint-Maximin gave the home side a seventh-minute lead with a fine individual effort, side-stepping two markers before he fired past De Gea.
Paul Pogba faces a race against time to prove his fitness for Monday's Premier League clash against Arsenal
Images from the English Premier League matches played on Sunday night.
Marcus Rashford scored twice as Manchester United extended their 100 percent record on the road, coming from behind again to win 3-2 at the English Premier League's bottom club Sheffield United on Thursday.
Manchester City have now won only once in 11 games in all competitions.
Leicester City reached the FA Cup final for the first time in more than 50 years
Saka, Jude Bellingham and Phil Foden -- the three youngest players in the England squad -- have been described as "generational talents", but the Arsenal player said they had learned to tune out the noise, be it compliments or criticism.
IMAGES from the Premier League matches played across England, on Sunday.
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
Manchester United and Tottenham Hotspur built hefty leads with emphatic away wins in their Europa League last 32 first-leg matches but AC Milan were held to a 2-2 draw at Red Star Belgrade as the competition resumed on Thursday.
Manchester United pull off one of the greatest comebacks in Champions League history.
'We must work towards a society that doesn't require Black players to prove their value or place in society only through victory. Ultimately everyone on the England team should be so proud of their achievement and how they represented us.'
Italy goalkeeper Gianluigi Donnarumma was named the player of Euro 2020 following Italy's 3-2 shootout win against England in the final at Wembley on Sunday.
Liverpool opened up an eight-point lead at the top of the Premier League with an emphatic and hugely impressive 3-1 win over defending champions Manchester City.
Wayne Rooney scored on his return to the Manchester United starting-line up as Jose Mourinho's side enjoyed a 2-0 win at Burnley in the Premier League on Sunday to close in on the top four and extend their unbeaten league run to 23 games.
Klopp says Liverpool's defending to blame for loss
A brilliantly-worked goal by Ryan Christie and a Justin Kluivert penalty gave Bournemouth shock 2-0 Premier League win at home to 10-man Arsenal.
IMAGES from the Premier League matches played on Sunday
IMAGES from the Premier League matches played on Saturday.
Moroccan Yassine Bono denied Marcus Rashford, Bruno Fernandes, Mason Greenwood and Anthony Martial in either half of the match to keep the match alive
Manchester United were dumped out of the FA Cup fourth round
Paul Pogba faces 'a few weeks'on the sidelines after injuring his hamstring.
Manchester United, Sevilla and Celtic led a parade of clubs with continental pedigree to book the first places in this season's Europa League knockout stage.
Liverpool's English Premier League title winning captain Jordan Henderson was named England's Footballer of the Year on Friday in the annual vote of the Football Writers' Association (FWA).
The spectator, in a letter of complaint to the ECB, also said women were subjected to sexist chants while homophobic abuse was directed at some players by the same group of people.
Didier Deschamps of France and Argentina's Lionel Scaloni should avoid the temptation to throw on a 'penalty specialist'
Manchester United showing 'concrete interest' in the French forward
Brighton and Hove Albion made sure of Premier League football next season with two games to spare after a Pascal Gross goal gave them a memorable 1-0 home win over Manchester United on Friday.
Sunderland striker Jermain Defoe was recalled to the England squad at the age of 34 on Thursday ahead of next week's friendly in Germany and a World Cup qualifier at home to Lithuania.
